|
| Status |
Public on Dec 31, 2015 |
| Title |
Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target [Seq] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
Expression profiling by high throughput sequencing
|
| Summary |
Multiple myeloma (MM) is a hematopoietic malignancy characterised by the accumulation of neoplastic post-germinal centre, isotype-switched, long-lived plasma cell within the bone marrow. In genetic and clinical terms MM is highly heterogeneous and remains fatal. Here we present the first epigenomic map of MM derived from freshly isolated bone marrow plasma cells from four patients. Using ChIP- and RNA-sequencing we define a set of silent H3K27me3 targets, active genes bearing H3K4me3, and bivalent genes.
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| Overall design |
Examination of 2 different histone modifications in four Multiple myeloma patients and two normal plasma cells samples. A single patient RNA-seq sample was also examined.
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| Contributor(s) |
Agarwal P, Alzrigat M, Párraga AA, Kalushkova A, Enroth S, Öberg F, Wiklund HJ |
| Citation(s) |
26755663 |
| Submission date |
Dec 11, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Prasoon Agarwal |
| E-mail(s) |
helena.jernberg_wiklund@igp.uu.se
|
| Organization name |
Rudbeck Laboratory, Uppsala University
|
| Department |
IGP
|
| Street address |
Dag Hammarshkojlds vag 20
|
| City |
Uppsala |
| State/province |
Sweden |
| ZIP/Postal code |
75185 |
| Country |
Sweden |
| |
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| Platforms (1) |
| GPL16558 |
AB 5500 Genetic Analyzer (Homo sapiens) |
|
| Samples (16)
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| This SubSeries is part of SuperSeries: |
| GSE69253 |
Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target |
|
| Relations |
| BioProject |
PRJNA231147 |
| SRA |
SRP033702 |
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