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Series GSE53520 Query DataSets for GSE53520
Status Public on Aug 01, 2014
Title Effect of in utero undernutrition on skeletal muscle gene expression
Organism Mus musculus
Experiment type Expression profiling by array
Summary In utero undernutrition is associated with obesity and insulin resistance, although its effect on skeletal muscle remains poorly defined. We report that, in mice, adult offspring from undernourished dams have decreased energy expenditure, decreased skeletal muscle mitochondrial content, and altered energetics in isolated mitochondria and permeabilized muscle fibers. Strikingly, when these mice are put on a 40% calorie restricted diet they lose half as much weight as calorie restricted controls. Our results reveal for the first time that in utero undernutrition alters metabolic physiology having a profound effect on skeletal muscle energetics and response to calorie restriction in adulthood.
 
Overall design We have used a mouse model of low birth weight generated through 50% food restriction of mouse dams during the third week of gestation. We have studied in utero food restricted offspring and control offspring that were not food restricted in utero in both the ad libitum and calorie restricted states. Gene expression profiling was performed on tibialis anterior muscle from 8 mice per group, pooled in pairs.
 
Contributor(s) Beauchamp BL, Ghosh S, Chu A, Blais A, Harper M
Citation(s) 25091727
Submission date Dec 19, 2013
Last update date May 10, 2023
Contact name Alexandre Blais
E-mail(s) alexandre.blais@uottawa.ca
Organization name University of Ottawa
Street address 451 Smyth Road
City Ottawa
State/province ON
ZIP/Postal code K1H 8M5
Country Canada
 
Platforms (1)
GPL7202 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)
Samples (16)
GSM1295431 tibialis anterior-MotherDiet_Control-OffspringDiet_Ad Lib-Rep1
GSM1295432 tibialis anterior-MotherDiet_Control-OffspringDiet_Ad Lib-Rep2
GSM1295433 tibialis anterior-MotherDiet_Control-OffspringDiet_Ad Lib-Rep3
Relations
BioProject PRJNA232265

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE53520_RAW.tar 29.8 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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