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Series GSE53552 Query DataSets for GSE53552
Status Public on Mar 31, 2014
Title Gene expression profiling in psoriatic lesional and non-lesional skin [brodalumab treatment]
Organism Homo sapiens
Experiment type Expression profiling by array
Summary To explore the psoriasis phenotype and pathways involved in psoriasis, we characterized gene expression in lesional and non-lesional skin from psoriasis patients. Furthermore, we explored the effects of various doses of brodalumab on lesional skin over time.
Overall design From each of the 25 psoriasis patients, we obtained two pre-dose biopsies, one from a lesion and the other from non-lesional skin in the same general body geography, and two post-dose biopsies. Total RNA was extracted from 6mm punch biopsies that were split in half. A total of 99 samples were run on Affymetrix HU133 Plus 2.0 microarrays. There was no paired non-lesional sample for 'T_lesional_pre-dose' (skn55789).
Contributor(s) Bigler J, Timour M, Kerkof K, Russell CB
Citation(s) 24646743
Submission date Dec 20, 2013
Last update date Mar 25, 2019
Contact name Jeannette Bigler
Organization name BJ Group, LLC
Street address 3200 NE 92nd Street
City Seattle
State/province WA
ZIP/Postal code 98115
Country USA
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (99)
GSM1296024 K_lesional_day15
GSM1296025 C_lesional_day15
GSM1296026 F_lesional_day15
BioProject PRJNA232372

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE53552_RAW.tar 532.0 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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