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| Status |
Public on Nov 20, 2006 |
| Title |
p400/mDomino-deficient mouse embryo proper |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The SWI2/SNF2 family ATPase, p400/mDomino, is a core subunit of a large chromatin-remodeling complex. The mDomino-deficient (mDom-/-) mice died by embryonic day 11.5, and displayed an anemic appearance and slight deformity of the neural tube. We examined the gene expression in the wild-type (GSM121658) and mDom-/- (GSM121659) E8.5 embryo proper, and found that all of the embryonic globin genes and a globin chaperone gene (AHSP) were poorly expressed in the mDom-/- embryo on embryonic day 8.5.
Keywords: Comparative gene expression analysis of wild-type and gene-targeted mice
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| Overall design |
Total RNA was prepared from mixtures of litter-matched embryos at E8.5 (wild-type embryos: n = 42, mDom-/- embryos: n = 45).
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| Contributor(s) |
Ueda T, Watanabe-Fukunaga R, Ogawa H, Fukuyama H, Higashi Y, Nagata S, Fukunaga R |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jul 20, 2006 |
| Last update date |
Mar 25, 2013 |
| Contact name |
Rikiro Fukunaga |
| E-mail(s) |
fukunaga@genetic.med.osaka-u.ac.jp
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| Phone |
81-6-6879-3318
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| Fax |
81-6-6879-3319
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| URL |
http://www.med.osaka-u.ac.jp/pub/genetic/index.html
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| Organization name |
Osaka University
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| Department |
Grad School Frontier Biosciences
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| Lab |
Genetics
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| Street address |
2-2 Yamadaoka
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| City |
Suita |
| State/province |
Osaka |
| ZIP/Postal code |
565-0871 |
| Country |
Japan |
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| Platforms (1) |
| GPL2897 |
GE Healthcare/Amersham Biosciences CodeLink™ Mouse Whole Genome Bioarray |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA96253 |
