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Series GSE54035 Query DataSets for GSE54035
Status Public on Jan 14, 2014
Title Dextran sodium sulfate treatment of Pirc rats alters colonic and tumor gene expression
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary Dextran sodium sulfate (DSS) causes inflammation in the gut similar to ulcerative colitis in humans. Patients with ulcerative colitis have increased risk of developing colon cancer. We sought to determine whether genes altered in the normal colonic epithelium or tumor differed between sporadic and inflammation-associated tumor development.
 
Overall design 97 day old (ACIxF344)F1-Pirc male rats either untreated or given 4% DSS in the drinking water from 40-47 and 54-61 days of age, housed in 12 hour light:12 dark, ad lib feeding and drinking conditions. Normal colonic tissue and tumors were harvested from the distal colon at 97 days of age. A two color, reference design experiment hybridized according to Agilent protocols against a reference pool of RNA made up from colon tissue taken from pooled wild type rats which was labeled with Cy5.
 
Contributor(s) Irving AA, Dove WF
Citation(s) 25200834, 30188895
Submission date Jan 13, 2014
Last update date Oct 29, 2018
Contact name Amy Irving
Organization name University of Wisconsin-Madison
Department McArdle Laboratory for Cancer Research
Lab William Dove
Street address 1400 University Avenue
City Madison
State/province WI
ZIP/Postal code 53706
Country USA
 
Platforms (1)
GPL4135 Agilent-014879 Whole Rat Genome Microarray 4x44K G4131F (Feature Number version)
Samples (24)
GSM1306199 Tumor_DSS_97d_rat1
GSM1306200 Normal_DSS_97d_rat1
GSM1306201 Normal_Control_97d_rat2
This SubSeries is part of SuperSeries:
GSE54036 Effects of dextran sodium sulfate on normal colonic tissue and tumors in wild type and Apc-Pirc/+ rats.
Relations
BioProject PRJNA235286

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE54035_Pirc_Fold_Changes.xls.gz 453.9 Kb (ftp)(http) XLS
GSE54035_RAW.tar 349.2 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
Processed data provided as supplementary file

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