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Status |
Public on Mar 06, 2014 |
Title |
Expression data from adult mouse normal and damaged retina from B6 and 129 mouse strains |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
Retinal damage causes proliferation of Muller glia, but the degree of proliferation depends on mouse strains. Muller glial proliferation was significantly promoted by the addition of GSK3 inhibitor in 129, but not in B6. We used retinal explant culture as a model for retinal damage which caused preferential photoreceptor death in a few days. We used microarrays to detail the global programme of gene expression regulating the proliferative potential of Muller glia after retinal damage.
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Overall design |
Total RNA from intact whole retina, retinal tissue cultured for three days, and retinal tissue cultured with chir99021 for three days was used. Retinal tissues from 10 weeks old mice were used.
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Contributor(s) |
Suga A, Takahashi M |
Citation(s) |
24747725 |
Submission date |
Jan 14, 2014 |
Last update date |
Feb 11, 2019 |
Contact name |
Masayo Takahashi |
Organization name |
RIKEN CDB
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Lab |
Laboratory for Retinal Regeneration
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Street address |
2-2-3 Minamimachi, Minatojima, Chu-o-ku
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City |
Kobe |
State/province |
Hyogo |
ZIP/Postal code |
650-0047 |
Country |
Japan |
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Platforms (1) |
GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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Samples (12)
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GSM1306529 |
intact retina from B6 mouse, biological rep1 |
GSM1306530 |
intact retina from B6 mouse, biological rep2 |
GSM1306531 |
B6 retinal explant cultured for three days, biological rep1 |
GSM1306532 |
B6 retinal explant cultured for three days, biological rep2 |
GSM1306533 |
B6 retinal explant cultured for three days with chir99021, biological rep1 |
GSM1306534 |
B6 retinal explant cultured for three days with chir99021, biological rep2 |
GSM1306535 |
intact retina from 129 mouse, biological rep1 |
GSM1306536 |
intact retina from 129 mouse, biological rep2 |
GSM1306537 |
129 retinal explant cultured for three days, biological rep1 |
GSM1306538 |
129 retinal explant cultured for three days, biological rep2 |
GSM1306539 |
129 retinal explant cultured for three days with chir99021, biological rep1 |
GSM1306540 |
129 retinal explant cultured for three days with chir99021, biological rep2 |
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Relations |
BioProject |
PRJNA234487 |
Supplementary file |
Size |
Download |
File type/resource |
GSE54056_RAW.tar |
43.8 Mb |
(http)(custom) |
TAR (of CEL) |
Processed data included within Sample table |
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