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Series GSE54056 Query DataSets for GSE54056
Status Public on Mar 06, 2014
Title Expression data from adult mouse normal and damaged retina from B6 and 129 mouse strains
Organism Mus musculus
Experiment type Expression profiling by array
Summary Retinal damage causes proliferation of Muller glia, but the degree of proliferation depends on mouse strains. Muller glial proliferation was significantly promoted by the addition of GSK3 inhibitor in 129, but not in B6. We used retinal explant culture as a model for retinal damage which caused preferential photoreceptor death in a few days.
We used microarrays to detail the global programme of gene expression regulating the proliferative potential of Muller glia after retinal damage.
 
Overall design Total RNA from intact whole retina, retinal tissue cultured for three days, and retinal tissue cultured with chir99021 for three days was used. Retinal tissues from 10 weeks old mice were used.
 
Contributor(s) Suga A, Takahashi M
Citation(s) 24747725
Submission date Jan 14, 2014
Last update date Feb 11, 2019
Contact name Masayo Takahashi
Organization name RIKEN CDB
Lab Laboratory for Retinal Regeneration
Street address 2-2-3 Minamimachi, Minatojima, Chu-o-ku
City Kobe
State/province Hyogo
ZIP/Postal code 650-0047
Country Japan
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (12)
GSM1306529 intact retina from B6 mouse, biological rep1
GSM1306530 intact retina from B6 mouse, biological rep2
GSM1306531 B6 retinal explant cultured for three days, biological rep1
Relations
BioProject PRJNA234487

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE54056_RAW.tar 43.8 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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