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Series GSE5447 Query DataSets for GSE5447
Status Public on Oct 16, 2006
Title p53 family members in myogenic differentiation and rhabdomyosarcoma development
Organism Mus musculus
Experiment type Expression profiling by array
Summary The p53 family comprises the tumor suppressor p53 and the structural homologs p63 and p73. How the three family members cooperate in tumor suppression remains unclear. Here, we report different but complementary functions of the individual members for regulating retinoblastoma protein (RB) function during myogenic differentiation. Whereas p53 transactivates the retinoblastoma gene, p63 and p73 induce the cyclin-dependent kinase inhibitor p57 to maintain RB in an active, hypophosphorylated state. DeltaNp73 inhibits these functions of the p53 family in differentiation control, prevents myogenic differentiation, and enables cooperating oncogenes to transform myoblasts to tumorigenicity. DeltaNp73 is frequently overexpressed in rhabdomyosarcoma and essential for tumor progression in vivo. These findings establish differentiation control as a key tumor suppressor activity of the p53 family.
Keywords: oligonucleotide
Overall design DeltaNp73 alpha expressing C2C12 myoblasts examined 6 and 24 hours after shifting the cells to a differentiation medium.
Contributor(s) Cam H, Griesman H, Burek C, Stiewe T
Citation(s) 17045206
Submission date Aug 03, 2006
Last update date Feb 11, 2019
Contact name Christof Burek
Phone ++49 (0)931 20147696
Organization name Universitaet Wuerzburg
Department Pathologie
Lab Rosenwald
Street address Josef-schneider-Str. 2
City Wuerzburg
ZIP/Postal code 97080
Country Germany
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (6)
GSM124854 p53 family members in myogenic differentiation mock 0 h
GSM124864 p53 family members in myogenic differentiation DeltaNp73 0 h
GSM124865 p53 family members in myogenic differentiation DeltaNp73 6h
BioProject PRJNA96121

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Supplementary data files not provided

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