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| Status |
Public on May 19, 2015 |
| Title |
Different molecular pathways along with pathogenesis of three subtypes of Leiomyosarcoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Leiomyosarcoma (LMS) is a malignant neoplasm of smooth muscle and is an aggressive soft tissue tumor, have complex genetic abnormalities and could be defined as three molecular subtypes. Since that the molecular heterogeneity of LMS, the pathogenesis analysis per subtype will be highly necessary and helpful to understand the etiology of this more common sarcoma.
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| Overall design |
Within this study, we collected four Myometrium, three Leiomyoma, three LMS cell lines and 99 LMSs (GSE45510), performed the system-wide gene expression profiling by 3'end RNA Sequencing, and found that there are significant different molecular pathways along the pathogenesis for those three molecular subtypes.
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| Contributor(s) |
Guo X, Zhu SX, Varma S, West RB, van de Rijn M |
| Citation(s) |
25896974 |
| Submission date |
Jan 29, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Xiangqian Guo |
| E-mail(s) |
xqguo@stanford.edu
|
| Phone |
650 725 7742
|
| Organization name |
Stanford University
|
| Department |
Department of Pathology
|
| Lab |
vanderijn-west Lab
|
| Street address |
300 Pasteur Dr.
|
| City |
Stanford |
| State/province |
CA |
| ZIP/Postal code |
94305 |
| Country |
USA |
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| Platforms (2) |
| GPL10999 |
Illumina Genome Analyzer IIx (Homo sapiens) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA236775 |
| SRA |
SRP036053 |
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