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| Status |
Public on Sep 15, 2014 |
| Title |
Leukocytes methylome of melanoma patients with and without CDKN2A mutations |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
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| Summary |
We investigated if the presence of germline CDKN2A mutations or the occurrence of cutaneous melanoma could induce constitutive genome-wide DNA methylation changes. We analyzed the leukocytes’ methylomes of eight patients carrying CDKN2A mutations, eight sporadic melanoma patients and compared them with healthy controls (n=8). The genome-wide DNA methylation profiling was obtained using the Infinium HumanMethylation450 BeadChip platform (Illumina).
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| Overall design |
Illumina 450k methylation array profiling performed on melanoma patients carrying germline CDKN2A mutations (n=8), sporadic melanoma patients (n=8) and health individuals (n=8)
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| Contributor(s) |
Araújo ÉS, Marchi FA, Rodrigues T, Vieira HC, Kuasne H, Achatz MW, Moredo LF, Sá BC, Duprat JP, Brentani H, Rosenberg C, Carraro DM, Krepischi AV |
| Citation(s) |
25236571 |
| Submission date |
Feb 12, 2014 |
| Last update date |
Mar 22, 2019 |
| Contact name |
Érica Sara Souza de Araújo |
| E-mail(s) |
erica.sara.araujo@gmail.com
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| Organization name |
A. C. Camargo Cancer Center
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| Department |
CIPE - Internacional Center for Research and Training
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| Street address |
Taguá st, 440
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| City |
Sao Paulo |
| State/province |
Sao Paulo |
| ZIP/Postal code |
01508010 |
| Country |
Brazil |
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| Platforms (1) |
| GPL13534 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA238059 |
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