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| Status |
Public on Apr 01, 2014 |
| Title |
Gene expression signature induced by 8 weeks of cigarette smoke exposure in the lung of BALB/c mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
To investigate the impact of cigarette smoke on lung gene expression, female BALB/c mice were obtained from Charles River at 6-8 weeks of age. Using a whole body exposure system (SIU48, PROMECH LAB AB, Vintrie, Sweden), mice (5 per group) were exposed to room air or the mainstream cigarette smoke of twelve 3R4F reference cigarettes (University of Kentucky, Lexington, USA) with filters removed 5 days per week, twice daily for 50 minutes/exposure for 8 weeks, as previously described. Control animals were exposed to room air only. Lungs were collected and stored in RNALater at -80°C prior to RNA extraction.
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| Overall design |
Impact of an 8 week cigarette smoke exposure on BALB/c mouse lung gene expression was assessed.
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| Contributor(s) |
Morissette MC, Lamontagne M, Bérubé J, Gaschler G, Halappanavar S, Stampfli MR, Bossé Y |
| Citation(s) |
24663285 |
| Submission date |
Feb 18, 2014 |
| Last update date |
May 10, 2018 |
| Contact name |
Mathieu C Morissette |
| E-mail(s) |
mathieu.morissette@criucpq.ulaval.ca
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| Organization name |
McMaster University
|
| Department |
Pathology and Molecular Biology
|
| Street address |
1280 Main St W
|
| City |
Hamilton |
| State/province |
Ontario |
| ZIP/Postal code |
L8S 4L8 |
| Country |
Canada |
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| Platforms (1) |
| GPL4134 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version) |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA238586 |
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