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Series GSE55540 Query DataSets for GSE55540
Status Public on May 12, 2014
Title Transcription profile of hearts extracted from zebrafish embryos treated with SU5402 at 48 hpf
Organism Danio rerio
Experiment type Expression profiling by array
Summary Heart formation requires input from two populations of progenitor cells - the first and second heart fields - that differentiate at distinct times and create different cardiac components. The cardiac outflow tract (OFT) is built through recruitment of late-differentiating, second heart field (SHF) -derived cardiomyocytes to the arterial pole of the heart. Mechanisms responsible for selection of an appropriate number of OFT cells from the SHF remain unclear, although several lines of evidence emphasize the importance of FGF signaling in promoting this process. Here, we examine the impact of inhibition of FGF signaling on cardiac transcription profiles in an effort to identify genes operating downstream of FGF during OFT development.
Overall design We compared hearts from embryos treated with the FGFR inhibitor SU5402 to the hearts from sibling embryos treated with DMSO. Two replicates were performed.
Contributor(s) Zeng XI, Yelon D
Citation(s) 24813897
Submission date Mar 04, 2014
Last update date Jan 25, 2018
Contact name Xin-Xin I. Zeng
Phone (858) 534-3212
Organization name UCSD
Department Division OF Biological Sciences
Lab Yelon
Street address 9500 Gilman Drive 0380
City La Jolla
State/province CA
ZIP/Postal code 92093-0380
Country USA
Platforms (1)
GPL1319 [Zebrafish] Affymetrix Zebrafish Genome Array
Samples (4)
GSM1338910 zebrafish_control_WT_Rep1
GSM1338911 zebrafish_SU5402 treated_Rep1
GSM1338912 zebrafish_control_WT_Rep2
BioProject PRJNA239951

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE55540_RAW.tar 8.2 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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