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| Status |
Public on Mar 13, 2014 |
| Title |
Down-regulation of CD9 by methylation decreased bortezomib sensitivity in multiple myeloma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Bortezomib therapy has been proven successful for the treatment of relapsed and/or refractory multiple myeloma (MM). However, both intrinsic and acquired resistance has already been observed. In this study, we explored the relationship between CD9 expression and bortezomib sensitivity in MM
Both intrinsic and acquired resistance has already been observed. In this study, we explored the relationship between CD9 expression and bortezomib sensitivity in MM. We found that down-regulation of CD9 by methylation decreased bortezomib sensitivity in multiple myeloma.
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| Overall design |
A six chip study using total RNA recovered from three separate wild-type cultures of U266 cells and three separate cultures of U266 with CD9 overexpression. Each chip measures the expression level of 45,033 genes from Homo sapiens with fourteen 60-mer probe pairs (PM/MM) per gene, with three-fold technical redundancy.
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| Contributor(s) |
Hu X |
| Citation(s) |
24788635 |
| Submission date |
Mar 12, 2014 |
| Last update date |
Sep 05, 2019 |
| Contact name |
Xiaotong Hu |
| E-mail(s) |
hxt_hangzhou@sina.com
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| Organization name |
Zhejiang University
|
| Street address |
Qingchun East Road #3
|
| City |
Hangzhou |
| ZIP/Postal code |
310016 |
| Country |
China |
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| Platforms (1) |
| GPL16025 |
NimbleGen Homo sapiens Expression Array [100718_HG18_opt_expr] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA241067 |
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