|
| Status |
Public on Sep 19, 2006 |
| Title |
Expression data from wild type versus HDAC knock out mouse embryonic stem cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Histone deacetylase 1 (HDAC1) is an enzyme that promotes deacetylation of acetylated lysine residues in histones and other proteins. Histone acetylation is often associated with gene activation and expression. Los of HDAC1 leads to severe problems in development and proliferation. Moreover, it seems to be the major histone deacetylase in mouse embryonic stem cells.
We used microarrays to identify putative HDAC1 target genes.
Keywords: Fold change anaylsis between wild type nad HDAC KO ES cells
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| |
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| Overall design |
Wild type and HDAC1 mouse embryonic stem cell, originating from same litter, were used for RNA extraction and hybridization on Affymetrix microarrays.
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| Contributor(s) |
Zupkovitz G, Posch M, Egger G, Schweifer N, Seiser C |
| Citation(s) |
16940178 |
| Submission date |
Aug 23, 2006 |
| Last update date |
Feb 18, 2018 |
| Contact name |
Gordin Zupkovitz |
| Organization name |
MFPL
|
| Department |
Medical Biochemistry
|
| Lab |
Seiser
|
| Street address |
Dr. Bohrgasse 9
|
| City |
Vienna |
| ZIP/Postal code |
A-1030 |
| Country |
Austria |
| |
|
| Platforms (1) |
| GPL81 |
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array |
|
| Samples (6)
|
| GSM130365 |
wild_type_embryonic_stem cells_biological_rep1 |
| GSM130366 |
wild_type_embryonic_stem cells_biological_rep2 |
| GSM130367 |
wild_type_embryonic_stem cells_biological_rep3 |
| GSM130368 |
HDAC1_knock_out_embryonic_stem_cells_biological_rep1 |
| GSM130369 |
HDAC1_knock_out_embryonic_stem_cells_biological_rep2 |
| GSM130370 |
HDAC1_knock_out_embryonic_stem_cells_biological_rep3 |
|
| Relations |
| BioProject |
PRJNA95449 |
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