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Series GSE56029 Query DataSets for GSE56029
Status Public on Feb 19, 2019
Title Defining the transcriptional signature of healing and non-healing lesions during murine cutaneous leishmaniasis
Organism Mus musculus
Experiment type Expression profiling by array
Summary Leishmaniasis is a group of diseases caused by parasites of the genus Leishmania that affects millions of people worldwide. The disease outcome is determined by both the parasite species and the host's immune response. Leishmania major infection causes a localized cutaneous lesion in patients and has been widely used to study the development of T cell responses in mice. L. major infected C57BL/6 mice are resistant to infection due to the development of Th1 responses, whereas BALB/c mice develop a Th2 response resulting in disease susceptibility and failure to control parasite replication. However, these disparate host phenotypes are not observed with all Leishmania species. For example, during L. braziliensis infection both BALB/c and C57BL/6 mice are resistant. In order to better understand the host genetic basis underlying disease susceptibility in vivo, we performed a whole genome transcriptional analysis from skin lesions of BALB/c and C57BL/6 mice infected intradermally for 4 weeks with either L. braziliensis or L. major.
 
Overall design twenty-four ear samples were recovered from either naïve mice or mice infected with Leishmania. For each infection, 4-5 mice were processed and the entire infected ear was recovered for RNA. Three naïve mice for each strain (Balb/c and C57BL/6) served as controls.
 
Contributor(s) Beiting D, Scott P, Novais F
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Submission date Mar 19, 2014
Last update date Feb 21, 2019
Contact name daniel beiting
E-mail(s) beiting@vet.upenn.edu
Organization name University of Pennsylvania
Department Pathobiology
Lab Beiting
Street address 380 S. University Ave
City Philadelphia
State/province PA
ZIP/Postal code 19104
Country USA
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (24)
GSM1350812 Balb.naive_1
GSM1350813 Balb.naive_2
GSM1350814 Balb.naive_3
Relations
BioProject PRJNA242643

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE56029_RAW.tar 3.1 Mb (http)(custom) TAR
GSE56029_non-normalized_data.txt.gz 2.5 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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