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| Status |
Public on May 16, 2014 |
| Title |
Transcriptomic analysis of human breast and prostate cancer cell lines on lysophosphatidic acid (LPA) stimulation |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
LPA is a natural bioactive lipid with growth factor-like functions due to activation of series of six G protein-coupled receptors (LPA1-6).
In this study we determine the LPA induced early-gene expression profile in three unrelated human cancer cell lines (MDA-MB-231, MCF7, PC3) with an objective to identify potential biomarker/s specifically upregulated through the activation of LPA receptor type 1 (LPA1)
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| Overall design |
MDA-MB-231, MCF7, PC3 cells were serum starved for 24h and then stimulated with LPA (1µM) for 45min. The controls were the serum starved unstimulated cells. Two replicates for each sample were included in this study. Microarray analysis was performed using a high-density oligonucleotide array (GeneChip Human Genome U133 plus 2.0 array, Affymetrix)
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| Contributor(s) |
David M, Peyruchaud O, Sahay D |
| Citation(s) |
24828490 |
| Submission date |
Mar 27, 2014 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Olivier Peyruchaud |
| E-mail(s) |
olivier.peyruchaud@inserm.fr
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| Phone |
0033478785738
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| Organization name |
INSERM U1033
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| Lab |
Pathophysiology, diagnosis and treatment of bone disease
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| Street address |
UFR de medicine Lyon Est (Domaine Laennec), 7-11 Rue Guillaume Paradin
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| City |
Lyon |
| State/province |
Rhone Alpes |
| ZIP/Postal code |
69372 |
| Country |
France |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA242799 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE56265_RAW.tar |
62.5 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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