GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE56323 Query DataSets for GSE56323
Status Public on Jun 01, 2014
Title Lin28 sustains early renal progenitors and induces Wilms tumor
Organism Mus musculus
Experiment type Expression profiling by array
Summary Wilms Tumor, the most common pediatric kidney cancer, evolves from the failure of terminal differentiation of the embryonic kidney. Here we show that over-expression of the heterochronic regulator Lin28 during kidney development in mice markedly expands nephrogenic progenitors by blocking their final wave of differentiation, ultimately resulting in pathology highly reminiscent of Wilms tumor.
Overall design Gene expression analysis was performed on a total of 8 kidneys samples, including 4 tumors samples from Lin28 transgenic mice and 4 control kidneys
Contributor(s) Urbach A, Daley G
Citation(s) 24732380
Submission date Mar 28, 2014
Last update date Jun 14, 2018
Contact name Achia Urbach
Phone 617-919-2012
Organization name Children's hospital
Department Hema/Onc
Lab George daley
Street address 1 Blakfan circle
City Boston
State/province MA
ZIP/Postal code 02115
Country USA
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (8)
GSM1359095 kidney tumor #1
GSM1359096 control kidney #1
GSM1359097 kidney tumor #2
BioProject PRJNA242912

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE56323_Non-normalized_data.txt.gz 826.3 Kb (ftp)(http) TXT
GSE56323_RAW.tar 3.1 Mb (http)(custom) TAR
Raw data are available on Series record
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap