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Series GSE56426 Query DataSets for GSE56426
Status Public on Jan 24, 2015
Title Expression data from proximal jejunum of WT vs. TLR2 KO mice after methotrexate (MTX) treatment
Organism Mus musculus
Experiment type Expression profiling by array
Summary The role of innate immunity in modulating severity of chemotherapy-induced complications is so far unclear. The aim of this study was to determine how TLR2 may influence MTX-induced mucositis in the small intestine in mice. We used microarrays to assess gene expression profiles in proximal jejunum of WT vs. TLR2 KO mice after systemic treatment with MTX.
 
Overall design Mucositis was induced by i.p. injection of MTX [40mg/kg BW/d] for 4 days in WT or TLR2 knockout (KO) mice. On day 7, mice were sacrificed and RNA was extracted from proximal jejunum (n=3 mice/group) and hybridized on Affymetrix microarrays.
 
Contributor(s) Cario E, Frank M
Citation(s) 25589072
Submission date Apr 01, 2014
Last update date Apr 18, 2017
Contact name Elke Cario
E-mail(s) elke.cario@uni-due.de
Phone +49-201-723-4527
Organization name University of Duisburg-Essen, University Hospital of Essen
Department Division of Gastroenterology and Hepatology
Lab Cario
Street address Virchowstr. 171
City Essen
State/province NRW
ZIP/Postal code 45147
Country Germany
 
Platforms (1)
GPL11533 [MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version]
Samples (12)
GSM1361232 WT, - MTX, biological rep1
GSM1361233 WT, - MTX, biological rep2
GSM1361234 WT, - MTX, biological rep3
Relations
BioProject PRJNA243285

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE56426_RAW.tar 51.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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