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Series GSE56630 Query DataSets for GSE56630
Status Public on Feb 18, 2015
Title Expression profiling of MDA-MB-231 breast cancer cells treated with DOT1L inhibitors and siDOT1L
Organism Homo sapiens
Experiment type Expression profiling by array
Summary MDA-MB-231 cell line with relatively high DOT1L levels was treated with two potent, selective inhibitors of the DOT1L histone methyl transferase. These compounds can inhibit cells migration and invasion and induce differentiation. Here we provide expression profiling data of cells treated with two DOT1L inhibitors [1] [2], DOT1L siRNA (siDOT1L) or control.
 
Overall design MDA-MB-231 cells were treated with 1uM compound [1], 5uM compound [1], 2uM compound [2], 10 uM compound [2] (DOT1L inhibitors) or control (0.1% DMSO) for 14 days, or siDOT1L for 7 days. For each unique condition, 2 biological replicates were generated for expression profiling.
Compound [1]: EPZ004777 (in Diagle et al., 2011)
Compound [2]: Compound 55 (in Anglin et al., 2012)
 
Contributor(s) Zhang L, Chen F, Song Y
Citation(s) 25359765
Submission date Apr 08, 2014
Last update date Aug 13, 2018
Contact name Yongcheng Song
Organization name BAYLOR COLLEGE OF MEDICINE
Department PHARMACOLOGY
Street address One baylor plaza, Baylor College of Medicine
City Houston
State/province TX
ZIP/Postal code 77030
Country USA
 
Platforms (1)
GPL10558 Illumina HumanHT-12 V4.0 expression beadchip
Samples (12)
GSM1366023 Control, biological rep.1
GSM1366024 Control, biological rep.2
GSM1366025 2uM compound [2], biological rep.1
Relations
BioProject PRJNA244410

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE56630_RAW.tar 26.2 Mb (http)(custom) TAR
GSE56630_non-normalized.txt.gz 2.5 Mb (ftp)(http) TXT
Processed data included within Sample table
Raw data are available on Series record

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