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| Status |
Public on Feb 18, 2015 |
| Title |
Expression profiling of MDA-MB-231 breast cancer cells treated with DOT1L inhibitors and siDOT1L |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
MDA-MB-231 cell line with relatively high DOT1L levels was treated with two potent, selective inhibitors of the DOT1L histone methyl transferase. These compounds can inhibit cells migration and invasion and induce differentiation. Here we provide expression profiling data of cells treated with two DOT1L inhibitors [1] [2], DOT1L siRNA (siDOT1L) or control.
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| Overall design |
MDA-MB-231 cells were treated with 1uM compound [1], 5uM compound [1], 2uM compound [2], 10 uM compound [2] (DOT1L inhibitors) or control (0.1% DMSO) for 14 days, or siDOT1L for 7 days. For each unique condition, 2 biological replicates were generated for expression profiling.
Compound [1]: EPZ004777 (in Diagle et al., 2011)
Compound [2]: Compound 55 (in Anglin et al., 2012)
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| Contributor(s) |
Zhang L, Chen F, Song Y |
| Citation(s) |
25359765 |
| Submission date |
Apr 08, 2014 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Yongcheng Song |
| Organization name |
BAYLOR COLLEGE OF MEDICINE
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| Department |
PHARMACOLOGY
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| Street address |
One baylor plaza, Baylor College of Medicine
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| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA244410 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE56630_RAW.tar |
26.2 Mb |
(http)(custom) |
TAR |
| GSE56630_non-normalized.txt.gz |
2.5 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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