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| Status |
Public on Dec 31, 2014 |
| Title |
Gene expression profile in the lung of mice during pneumococcal pneumonia: WT vs NLRP3 inflammasome component-deficient mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Inflammasomes are multiprotein platforms of caspase-1 activation. The NLRP3 inflammasome is composed of NLRP3, ASC, and procaspase-1. This inflammasome is activated by various endogenous and exogenous stimuli, including pneumococci, and protects from a variety of microbial pathogens.
In the present study, we examined the role of NLRP3 inflammasome components in gene expression in the lung during pneumococcal pneumina.
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| Overall design |
Gene expression was measured in the lung of WT, Casp1-/-, Asc-/-, and Nlrp3-/- mice 24 h after intranasal infection with Streptococcus pneuminiae.
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| Contributor(s) |
Fang R, Sakai S |
| Citation(s) |
31278375 |
| Submission date |
Apr 09, 2014 |
| Last update date |
Jul 10, 2019 |
| Contact name |
Kohsuke Tsuchiya |
| E-mail(s) |
tsuchiya@mb.med.kyoto-u.ac.jp
|
| Phone |
+81-75-753-4443
|
| Organization name |
Kyoto University
|
| Department |
Microbiology
|
| Street address |
Yoshida Konoe-cho, Sakyo-ku
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| City |
Kyoto |
| ZIP/Postal code |
606-8501 |
| Country |
Japan |
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| Platforms (1) |
| GPL13912 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Feature Number version) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA244243 |
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