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Series GSE56843 Query DataSets for GSE56843
Status Public on Apr 16, 2014
Title Steroid Receptor Coactivator 1 is an Integrator of Glucose and NAD(+)/NADH Homeostasis
Organism Homo sapiens
Experiment type Expression profiling by array
Summary SRC-1 affects the expression of complex I of the mitochondrial electron transport chain, a set of enzymes responsible for the conversion of NADH to NAD(+). NAD(+) and NADH were subsequently identified as metabolites that underlie SRC-1's response to glucose deprivation. Knockdown of SRC-1 in glycolytic cancer cells abrogated their ability to grow in the absence of glucose consistent with SRC-1's role in promoting cellular adaptation to reduced glucose availability
Overall design RNA profiling was used to examine the effects of SRC-1 perturbation on gene expression in the absence or presence of glucose.
Contributor(s) Motamed M, Rajapakshe KI, Hartig SM, Coarfa C, Moses RE, Lonard DM, O'Malley BW
Citation(s) 24438340
Submission date Apr 16, 2014
Last update date Mar 25, 2019
Contact name David Lonard
Organization name Baylor College of Medicine
Department Mol & Cell Biology-Mol.Regulation
Lab BCM-Michael Debakey Center, Room M809, MS: BCM130
Street address 1 Baylor Plaza
City Houston
State/province TX
ZIP/Postal code 77030
Country USA
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (8)
GSM1370129 sictrl without glucose, biological rep1
GSM1370130 sictrl without glucose, biological rep2
GSM1370131 sictrl with glucose, biological rep1
BioProject PRJNA244751

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Supplementary file Size Download File type/resource
GSE56843_RAW.tar 37.1 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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