NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE56894 Query DataSets for GSE56894
Status Public on May 01, 2015
Title Transcriptional response in normal tissues in mice after 211At administration - dependency of absorbed dose, dose-rate and time
Organism Mus musculus
Experiment type Expression profiling by array
Summary RNA microarray analysis of low-dose and dose rate responses versus time after i.v. administration of 211At.
Female BALB/c nude mice were intravenously injected with 1.7 kBq 211At and killed after 1 h, 6 h, or 7 d, or injected with 105 or 7.5 kBq and killed after 1 h and 6 h, respectively.
Controls were mock-treated. Kidneys, liver, lungs, and spleen were excised, flash-frozen, and stored at -80°C.
Total RNA was extracted and subjected to expression analysis using RNA microarray technology.
Enriched biological processes were categorized after cellular function based on Gene Ontology terms.
 
Overall design Total RNA was isolated from fresh-frozen tissue samples. Three mice per group were used for 1.7 kBq 211At injections and controls; two mice per group for 105 and 7.5 kBq injections.
 
Contributor(s) Langen B, Rudqvist N, Parris TZ, Schüler E, Spetz J, Helou K, Forssell-Aronsson E
Citation(s) 25853007
Submission date Apr 17, 2014
Last update date Jun 14, 2018
Contact name Britta Langen
E-mail(s) britta.langen@gu.se
Organization name Sahlgrenska Academy at University of Gothenburg
Department Department of Radiation Physics
Street address Gula stråket 2B
City Gothenburg
ZIP/Postal code SE-413 45
Country Sweden
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (80)
GSM1370752 211At_cortex_1.7kBq_1h_#1
GSM1370753 211At_cortex_1.7kBq_1h_#2
GSM1370754 211At_cortex_1.7kBq_1h_#3
Relations
BioProject PRJNA244873

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE56894_Non-normalized_data.txt.gz 11.9 Mb (ftp)(http) TXT
GSE56894_RAW.tar 3.1 Mb (http)(custom) TAR
Raw data are available on Series record
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap