NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE56988 Query DataSets for GSE56988
Status Public on May 02, 2014
Title Timecourse analysis of Ezh2-dependent gene expression by SVZ NSCs during differentiation
Organism Mus musculus
Experiment type Expression profiling by array
Summary Previous work had established that Ezh2-deleted neural stem cells (NSCs) from the postnatal mouse subventricular zone (SVZ) had a deficit in both proliferation and neuronal differentiation both in vivo and in vitro. Ezh2-deleted NSCs in an Ink4a/Arf-deleted background proliferated normally but still displayed a neurogenesis defect, suggesting that Ezh2 is necessary for the proper expression of genes responsible for neuronal differentiation. Our results identify genes that are differentially regulated between control and Ezh2-deleted SVZ NSCs during differentiation.
 
Overall design Total RNA obtained from SVZ NSCs 0, 1, 2, 4, and 7 days after switching from proliferation to differentiation media.
 
Contributor(s) Hwang WW, Lim DA, Kelley KW, Oldham MC
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Apr 23, 2014
Last update date Jun 14, 2018
Contact name William Hwang
Organization name UCSF
Department Neurosurgery
Lab Lim
Street address Lim Lab - Box 0525, 35 Medical Center Way
City San Francisco
State/province CA
ZIP/Postal code 94143
Country USA
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (24)
GSM1372651 Control_0day_1
GSM1372652 Control_0day_2
GSM1372653 Control_0day_3
Relations
BioProject PRJNA245174

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE56988_RAW.tar 3.1 Mb (http)(custom) TAR
GSE56988_non-normalized.txt.gz 3.6 Mb (ftp)(http) TXT
Processed data included within Sample table
Raw data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap