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Series GSE56988 Query DataSets for GSE56988
Status Public on May 02, 2014
Title Timecourse analysis of Ezh2-dependent gene expression by SVZ NSCs during differentiation
Organism Mus musculus
Experiment type Expression profiling by array
Summary Previous work had established that Ezh2-deleted neural stem cells (NSCs) from the postnatal mouse subventricular zone (SVZ) had a deficit in both proliferation and neuronal differentiation both in vivo and in vitro. Ezh2-deleted NSCs in an Ink4a/Arf-deleted background proliferated normally but still displayed a neurogenesis defect, suggesting that Ezh2 is necessary for the proper expression of genes responsible for neuronal differentiation. Our results identify genes that are differentially regulated between control and Ezh2-deleted SVZ NSCs during differentiation.
Overall design Total RNA obtained from SVZ NSCs 0, 1, 2, 4, and 7 days after switching from proliferation to differentiation media.
Contributor(s) Hwang WW, Lim DA, Kelley KW, Oldham MC
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Submission date Apr 23, 2014
Last update date Jun 14, 2018
Contact name William Hwang
Organization name UCSF
Department Neurosurgery
Lab Lim
Street address Lim Lab - Box 0525, 35 Medical Center Way
City San Francisco
State/province CA
ZIP/Postal code 94143
Country USA
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (24)
GSM1372651 Control_0day_1
GSM1372652 Control_0day_2
GSM1372653 Control_0day_3
BioProject PRJNA245174

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE56988_RAW.tar 3.1 Mb (http)(custom) TAR
GSE56988_non-normalized.txt.gz 3.6 Mb (ftp)(http) TXT
Processed data included within Sample table
Raw data are available on Series record

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