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Status |
Public on Jul 28, 2015 |
Title |
Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
IL13Rα2 overexpression promotes metastasis of basal-like breast cancers IL13Rα2 depletion in highly metastatic breast cancer cells suppresses lung metastases formation by upregulating TP63 and decreasing their migratory potential
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Overall design |
MCF10CA1a (MIV) cells expressing the luciferase gene (MIV-Luc), were stably transduced with lentiviral constructs expressing either scrambled shRNA or shRNA against IL13Rα2. The two cell lines were then either mock treated or treated with 20ng/ml IL13 for 16h followed by RNA isolation. Gene expression analysis was performed using the Affymetrix Human Exon 1.0 ST platform. Array data was processed by Affymetrix Exon Array Computational Tool.
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Contributor(s) |
Papageorgis P, Tzatsos A, Ruf N, Thiagalingam S, Constantinou A |
Citation(s) |
26208975 |
Submission date |
May 14, 2014 |
Last update date |
Jul 26, 2018 |
Contact name |
Panagiotis Papageorgis |
E-mail(s) |
ppapageo@ucy.ac.cy
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Phone |
+357-22892244
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Organization name |
University of Cyprus
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Department |
Biological Sciences
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Street address |
75, Kallipoleos avenue
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City |
Nicosia |
ZIP/Postal code |
1678 |
Country |
Cyprus |
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Platforms (1) |
GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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Samples (8)
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Relations |
BioProject |
PRJNA247609 |