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| Status |
Public on Jul 28, 2015 |
| Title |
Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
IL13Rα2 overexpression promotes metastasis of basal-like breast cancers
IL13Rα2 depletion in highly metastatic breast cancer cells suppresses lung metastases formation by upregulating TP63 and decreasing their migratory potential
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| Overall design |
MCF10CA1a (MIV) cells expressing the luciferase gene (MIV-Luc), were stably transduced with lentiviral constructs expressing either scrambled shRNA or shRNA against IL13Rα2. The two cell lines were then either mock treated or treated with 20ng/ml IL13 for 16h followed by RNA isolation. Gene expression analysis was performed using the Affymetrix Human Exon 1.0 ST platform. Array data was processed by Affymetrix Exon Array Computational Tool.
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| Contributor(s) |
Papageorgis P, Tzatsos A, Ruf N, Thiagalingam S, Constantinou A |
| Citation(s) |
26208975 |
| Submission date |
May 14, 2014 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Panagiotis Papageorgis |
| E-mail(s) |
ppapageo@ucy.ac.cy
|
| Phone |
+357-22892244
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| Organization name |
University of Cyprus
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| Department |
Biological Sciences
|
| Street address |
75, Kallipoleos avenue
|
| City |
Nicosia |
| ZIP/Postal code |
1678 |
| Country |
Cyprus |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA247609 |
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