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Series GSE57738 Query DataSets for GSE57738
Status Public on Aug 20, 2014
Title T cell-intrinsic MyD88 signaling in cognate immune response to intracellular parasite infection: crucial role for IL-18R
Organism Mus musculus
Experiment type Expression profiling by array
Summary We compared gene expression between WT CD4+ (CD45.1) and Myd88-/- CD4+ (CD45.2) T cells from the spleen of infected mix bone marrow chimeras at day 14 of T. cruzi infection. The hypothesis studied in this experiment was that MyD88-/- CD4+ cells have suppressed Th1 differentiation potencial when compared to WT CD4+ T cells. The results indicate that CD4+ T cell-intrinsic MyD88 signaling is necessary for sustaining a more robust Th1 differentiation program and increased expansion among WT CD4+ T cells, resultant of relative higher proliferation and lower apoptosis
Overall design Total RNA obtained from isolated CD4+ T cells from the spleen of infected mix bone marrow chimeras at day 14 of T. cruzi infection.
Contributor(s) Reis BS, Bellio M, Nakaya HI, Nóbrega A
Citation(s) 28895840
Submission date May 16, 2014
Last update date Jul 10, 2019
Contact name Bernardo Reis
Organization name Rockefeller University
Street address 1234 York Avenue
City New York
State/province NY
ZIP/Postal code 10065
Country USA
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (4)
GSM1387885 sorted spleenic WT CD4+ T cells rep1
GSM1387886 sorted spleenic WT CD4+ T cells rep2
GSM1387887 sorted spleenic MyD88-/- CD4+ T cells rep1
BioProject PRJNA247979

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Supplementary file Size Download File type/resource
GSE57738_RAW.tar 3.1 Mb (http)(custom) TAR
GSE57738_non_normalized.txt.gz 1.7 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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