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| Status |
Public on Jun 06, 2014 |
| Title |
Influence of DEN in mice liver |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Hepatocellular carcinoma is the third leading cause of cancer death worldwide, and it is necessary to elucidate the mechanism of hepatocarcinogenesis. Hepatocellular carcinoma (HCC) has a high mortality rate and develops based on the chronic inflammatory hepatic disease. Therefore, novel prophylactic or therapeutic strategies are required to improve outcome. In this study, influence of diethylnitrosamine (DEN) and retinoic acid (ATRA) on hepatocarcinogenesis was investigated in mouse. These results suggest that the control of NF-κB signaling during the early stage of HCC development is important for the prevention of malignant transformation in hepatocytes.
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| Overall design |
Genes induced by the following treatments in mice liver were investigated at 2 days or 7 days after treatment;
DEN: diethylnitrosamine (treatment of DEN (drinking water 80 mg/L))
ATRA: retinoic acid (treatment of ATRA (drinking water 30 mg/L))
G0s2 siRNA : G0s2 knockdown mouse liver (treatment of G0s2 siRNA)
Control siRNA: treatment of scramble siRNA (negative control)
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| Contributor(s) |
Matsunaga N, Doi A, Yasuda K, Ohdo S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
May 19, 2014 |
| Last update date |
Feb 02, 2018 |
| Contact name |
naoya matsunaga |
| E-mail(s) |
matunaga@phar.kyushu-u.ac.jp
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| Organization name |
kyushu university
|
| Street address |
maidashi 3-1-1, higashi-ku
|
| City |
fukuoka |
| ZIP/Postal code |
8128582 |
| Country |
Japan |
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| Platforms (1) |
| GPL10787 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Probe Name version) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA248119 |
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