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Status |
Public on Aug 27, 2007 |
Title |
Expression data from T-cell prolymphocytic leukemia (TPLL) and normal T cells |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
T-cell prolymphocytic leukemina (T-PLL) is an agressive lymphoma derived from mature T-cells, which is in most cases characterized by the presence of an inv(14)(q11q32) and a characteristic pattern of secondary chromosomal abberations. We used microarrays to compare the transcriptomes of eight immunomagnetically purified CD3+ normal donor derived peripheral blood cells with five highly purified inv(14)-positive T-PLL blood samples. Keywords: desease state analysis
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Overall design |
Purified T-PLL cells and normal T-cells were analyzed on microarrays to identify differentially expressed genes. High-resolution copy number determination using SNP-chip technology and FISH in twelve inv(14)-positive T-PLL showed that differentially expressed genes clustered significantly in regions affectd by recurrent chromosomal imbalances.
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Contributor(s) |
Dürig J, Bug S, Klein-Hitpass L, Boes T, Jöns T, Martin-Dubero JI, Harder L, Baudis M, Dührsen U, Siebert R |
Citation(s) |
17713554, 19750229 |
Submission date |
Sep 07, 2006 |
Last update date |
Mar 24, 2020 |
Contact name |
Ludger Klein-Hitpass |
E-mail(s) |
ludger.klein-hitpass@uni-essen.de
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Phone |
+49 201 723 85552
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Organization name |
Institut fuer Zellbiologie
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Department |
Universitaetsklinikum
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Lab |
BioChip Lab
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Street address |
Virchowstr. 173
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City |
Essen |
ZIP/Postal code |
D-45122 |
Country |
Germany |
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Platforms (1) |
GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
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Samples (14)
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GSM135264 |
T-cell prolymphocytic leukemia, inv(14)(q11q32), case 1 |
GSM135265 |
T-cell prolymphocytic leukemia, inv(14)(q11q32), case 2 |
GSM135266 |
T-cell prolymphocytic leukemia, inv(14)(q11q32), case 3 |
GSM135267 |
T-cell prolymphocytic leukemia, inv(14)(q11q32), case 4 |
GSM135268 |
T-cell prolymphocytic leukemia, inv(14)(q11q32), case 5 |
GSM135269 |
T-cell prolymphocytic leukemia, no inv(14)(q11q32), case 8 |
GSM135270 |
Normal T-cells, CD3+, donor 1 |
GSM135271 |
Normal T-cells, CD3+, donor 2 |
GSM135272 |
Normal T-cells, CD3+, donor 3 |
GSM135273 |
Normal T-cells, CD3+, donor 4 |
GSM135274 |
Normal T-cells, CD3+, donor 5 |
GSM135275 |
Normal T-cells, CD3+, donor 6 |
GSM135276 |
Normal T-cells, CD3+, donor 7 |
GSM135277 |
Normal T-cells, CD3+, donor 8 |
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Relations |
BioProject |
PRJNA97145 |
Supplementary file |
Size |
Download |
File type/resource |
GSE5788_RAW.tar |
46.8 Mb |
(http)(custom) |
TAR (of CEL) |
Processed data included within Sample table |
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