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| Status |
Public on Sep 08, 2006 |
| Title |
Effect of 13 weeks of subchronic exposure to TCDD, PeCDF, PCB126, PCB153 and PCB126/PCB153 on hepatic gene expression |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
|
| Summary |
This study investigates the effects of the aryl hydrocarbon receptor (AhR) ligands TCDD, PCB126 and PeCDF; the non-AhR ligand PCB153 and the binary mixture PCB126/PCB153 on hepatic gene expression in female sprague dawley rats. Rats were treated with toxicological equivalent doses of TCDD (100ng/kg), PeCDF (200ng/kg), PCB126 (1000ng/kg) and PCB153 (1000ug/kg) 5 days a week for 13 weeks.
Keywords: Environmental pollutant toxicity comparison
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| Overall design |
There are 6 control chips and representing animals treated with vehicle control. There are 3 biological replicates (3 chips) for each treatment group (eg. TCDD, PCB126), each biological replicate is derived from 2 individual animals. A total of 21 chips were analyzed. Intensities were normalized using the GC-Robust Multiarray (GCRMA) method through Genetraffic software package.
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| Contributor(s) |
Ovando BJ, Olson JR, Vezina CM |
| Citation(s) |
16984957, 20959002 |
| Submission date |
Sep 07, 2006 |
| Last update date |
Feb 21, 2017 |
| Contact name |
Bladimir Jason Ovando |
| E-mail(s) |
bovando@buffalo.edu
|
| Phone |
716-829-3066
|
| Organization name |
University at Buffalo
|
| Department |
Pharmacology & Toxicology
|
| Lab |
James R. Olson
|
| Street address |
102 Farber Hall
|
| City |
Buffalo |
| State/province |
NY |
| ZIP/Postal code |
14214 |
| Country |
USA |
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| Platforms (1) |
| GPL85 |
[RG_U34A] Affymetrix Rat Genome U34 Array |
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| Samples (21)
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| Relations |
| BioProject |
PRJNA97147 |
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