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Series GSE5800 Query DataSets for GSE5800
Status Public on Oct 01, 2006
Title Expression data from mouse IRF6 null and wt skin
Organism Mus musculus
Experiment type Expression profiling by array
Summary Transcription factor paralogs may share a common role (e.g. Hox) in staged or overlapping expression in specific tissues. In other examples, members have distinct roles in a range of embryologic, differentiation or response pathways (e.g. Tbx, Pax). For the Interferon Regulatory Factor (IRF) family of transcription factors, mice deficient in Irf1, Irf2, Irf3, Irf4, Irf5, Irf7, Irf8 or Irf9, have defects in the immune response but display no embryologic abnormalities. Mice deficient for Irf6 have not been reported, but in humans, mutations in IRF6 cause two Mendelian orofacial clefting syndrome, and genetic variation in IRF6 confers risk for isolated cleft lip and palate.
Mice deficient for Irf6 have abnormal skin, limb and craniofacial development. Histological and gene expression analyses indicate that the primary defect is in keratinocyte differentiation and proliferation. This study describes a novel role for an IRF family member in epidermal development.
Keywords: Comparison of tissue from two genotypes
Overall design Skin from E17.5 mice was removed and flash frozen for RNA extraction and hybridization on Affymetrix microarrays.
Contributor(s) Ingraham C, Kinoshita A, Kondo S, Yang B, Sajan S, Trout K, Malik M, Dunnwald M, Goudy S, Lovett M, Murray J, Schutte B
Citation(s) 17041601
Submission date Sep 08, 2006
Last update date Feb 11, 2019
Contact name David Michael Alvarado
Phone 314-747-1063
Organization name Washington University in St. Louis
Department Genetics
Lab Michael Lovett
Street address 4565 Scott Ave
City St. Louis
State/province MO
ZIP/Postal code 63110
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (6)
GSM135470 IRF6 knockout, biological rep1
GSM135471 IRF6 knockout, biological rep2
GSM135472 IRF6 knockout, biological rep3
BioProject PRJNA97169

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