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| Status |
Public on Jun 07, 2014 |
| Title |
Liver Transcriptomics data from mouse model with Features of Post-traumatic Stress Disorder |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We have used a social defeat (SD) mouse model of post-traumatic stress disorder (PTSD) that is based on a brief exposure of a mouse to the aggressor mice for either 5 d or 10 d stress periods.
Mice simulating aspects of posttraumatic stress disorder exhibit behavioral changes, body weight gain, increased body temperature, and inflammatory and fibrotic histopathologies and transcriptomic changes of heart tissue. Liver tissue of these mice was subjected to mRNA analysis. Transcriptomic analysis of liver indicated chronic toxicities and metabolic alterations in aggressor-exposed mice that possibly contributed to the persistent metabolic disturbance
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| Overall design |
Two-condition experiment, C57BL6/J mice Biological replicates: 4-6 control replicates, 5-6 stressed replicates.
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| Contributor(s) |
Gautam A, D’Arpa P, Donohue D, Muhie S, Miller S, Chakraborty N, Hammamieh R, Jett M, Jibitu M |
| Citation(s) |
25629821 |
| Submission date |
Jun 06, 2014 |
| Last update date |
May 10, 2018 |
| Contact name |
Meskerem Jibitu |
| E-mail(s) |
Meskerem.S.Jibitu.ctr@mail.mil
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| Phone |
301-619-9623
|
| Organization name |
US Army Center for Environmental Health Research
|
| Department |
Integrative Systems Biology
|
| Street address |
568 Doughten Drive
|
| City |
Fort Detrick |
| ZIP/Postal code |
21702-5010 |
| Country |
USA |
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| Platforms (1) |
| GPL4134 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version) |
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| Samples (39)
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| Relations |
| BioProject |
PRJNA251877 |
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