|
| Status |
Public on Mar 12, 2008 |
| Title |
Expression data from transplanted intestine bifor signs of rejection, and when their was signs of rejection |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Acute cellular rejection (ACR) is the major cause of intestinal graft loss. Little is known about the genetic response occurring in small bowel transplantation (SBTx) during ACR. We report the case of a 44 year-old female with short gut syndrome following multiple surgeries for familial adenomatous polyposis that underwent living-related SBTx. We obtained for the first time a gene expression profile of the intestinal graft during ACR. Microarray analysis revealed increased transcript levels for genes that match identically to an IFN? signature reported for activated plasmacytoid dendritic cells and T-cell chemotaxis and cytolysis correlating with the diagnosis of ACR.
Keywords: disease state analysis
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| |
|
| Overall design |
sam1, sam2, sam3 (without signs of rejection)
sam4, sam5, sam6 (with signs and symptoms of rejection , histology showed increasing lymphocyte infiltration in the lamina propria and epithelium)
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| |
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| Contributor(s) |
Bradley SP, Elias GM, Brown ML, Pahari MP, Bannar B, Rastellini C, Cicalese L |
| Citation missing |
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| Submission date |
Sep 14, 2006 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Georg Elias |
| E-mail(s) |
georg.elias@umassmed.edu
|
| Phone |
508 856 8986
|
| Organization name |
UMASSMED
|
| Department |
Surgery/ Transplant
|
| Lab |
Cell Transplant/ Cicalese
|
| Street address |
377 plantation St/ Biotech 4
|
| City |
worcester |
| State/province |
MA |
| ZIP/Postal code |
01605 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (6)
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| Relations |
| BioProject |
PRJNA97233 |
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