 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Dec 10, 2007 |
| Title |
Gene expression profiles in TNBS-induced murine colitis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
We investigated the relationship between chronic inflammation and fibrosis in a mouse model of chronic colitis. Six weekly Trinitrobenzenesulphonic acid (TNBS) enemas were given to establish colitis and temporal changes in gene expression was elucidated over the next six weeks.
Keywords: disease state analysis
|
| |
|
| Overall design |
After the six TNBS enemas, mice were sacrificed at 3 days (termed as TNBS-w6, n=6), 2 weeks (TNBS-w8, n=4), 4 weeks (TNBS-w10, n=5), or 6 weeks (TNBS-w12, n=4). The saline control groups were also sacrificed at week 6 (Saline-w6, n=5), week 8 (n=2) and week 10 (n=2). The last two sets were pooled as Saline-w10 (n=4). Two replicates of saline-w6 were analyzed. We compared Saline-w6 with TNBS-w6, and Saline-w10 with TNBS-w8, TNBS-w10, TNBS-w12, respectively.
|
| |
|
| Contributor(s) |
Wu F, Chakravarti S |
| Citation(s) |
17982090 |
| Submission date |
Sep 18, 2006 |
| Last update date |
Feb 18, 2018 |
| Contact name |
Shukti Chakravarti |
| E-mail(s) |
schakrav@jhmi.edu
|
| Phone |
410-502-7627
|
| Fax |
410-614-4834
|
| Organization name |
Johns Hopkins University School of Medicine
|
| Department |
Medicine
|
| Lab |
935 Ross Bldg/ GI division
|
| Street address |
720 Rutland Ave
|
| City |
Baltimore |
| State/province |
MD |
| ZIP/Postal code |
21205 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL81 |
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array |
|
| Samples (7)
|
|
| Relations |
| BioProject |
PRJNA97275 |
| Supplementary data files not provided |
| Processed data included within Sample table |
|
|
|
|
 |
Less...
More...