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| Status |
Public on Oct 23, 2014 |
| Title |
The Drosophila Tis11 protein and its effects on mRNA expression in flies |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Insects generally express one tristetraprolin family member, proteins that in mammals promote mRNA decay. The Drosophila protein, Tis11, can promote mRNA decay in cells, and its deficiency in flies results in major changes in mRNA levels. Tis11 deficiency in Drosophila results in accumulation of potentialtarget transcripts. Tis11 can affect post- transcriptional gene expression in adult flies by regulating mRNA decay.
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| Overall design |
Examination of gene expression differences between wild-type, Tis11-knockout, and Tis11-mutated flies
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| Contributor(s) |
Blachshear PJ, Choi Y, La WS, Gersch ED, Huang W, Wilson GM, Fedic R, Stumpo DJ, Perera L, Brewer BY, Mason JM |
| Citation(s) |
25342740 |
| Submission date |
Jun 30, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Perry J Blackshear |
| E-mail(s) |
black009@niehs.nih.gov
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| Phone |
919-541-4926
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| Organization name |
NIEHS
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| Street address |
101 Alexander Dr.
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| City |
Durham |
| ZIP/Postal code |
27709 |
| Country |
USA |
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| Platforms (2) |
| GPL11203 |
Illumina Genome Analyzer IIx (Drosophila melanogaster) |
| GPL13304 |
Illumina HiSeq 2000 (Drosophila melanogaster) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA253952 |
| SRA |
SRP043687 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE58937_FPKM_data.txt.gz |
2.7 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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