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Series GSE59244 Query DataSets for GSE59244
Status Public on Oct 07, 2014
Title Affymetrix SNP array data for 5q- myelodysplastic syndromes
Organism Homo sapiens
Experiment type Genome variation profiling by SNP array
SNP genotyping by SNP array
Summary Myelodysplastic syndromes (MDS) are uncommon entities, heterogeneous clinically and cytogenetically. Recently, a new drug, Lenalidomide, has demonstrated to be very effective in patients with MDS and 5q- reaching 70% of hematological responses whereas patients with MDS without 5q- has only 20-30% of hematological responses. The aim of the present study is to determine genetic alteration in this subset of patients, and describe candidate genes related with response or resistance to Lenalidomide.
 
Overall design The aim of the present study is to determine genetic alteration in this subset of patients, and describe candidate genes related with response or resistance to Lenalidomide.
Copy number analysis of Affymetrix GenomeWide SNP 6.0 arrays was performed for 2 patients with MDS an isolated 5q- by conventional cytogenetics. There are also 2 samples from separated CD3+ lymphocytes, which were used as references for copy number and LOH inference.
 
Contributor(s) Solé F, Adema V
Citation(s) 25242043
Submission date Jul 09, 2014
Last update date Nov 27, 2018
Contact name Vera Adema
E-mail(s) vera.adema@gmail.com
Organization name Josep Carreras Leukaemia Research Institute
Department MDS Group
Street address Carretera de Can Ruti, Cami de les Escoles s/n
City Badalona
ZIP/Postal code 08916
Country Spain
 
Platforms (1)
GPL6801 [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array
Samples (4)
GSM1431245 Whole bone marrow_MD253
GSM1431246 CD3+_CD3_253
GSM1431247 Whole bone marrow_MD27
Relations
BioProject PRJNA254802

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE59244_RAW.tar 256.1 Mb (http)(custom) TAR (of CEL, CNCHP)
Processed data included within Sample table
Processed data provided as supplementary file

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