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Series GSE593 Query DataSets for GSE593
Status Public on Oct 17, 2003
Title Uterine Fibroid and Normal Myometrial Expression Profiles- U133 Arrays
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Our study seeks to identify genes differentially expressed between uterine leiomyomas and normal myometrial tissue. This series consists of samples derived from normal myometrium and uterine leiomyomas obtained from fibroid afflicted patients.Total RNA was extracted from samples, converted to biotin-labeled cRNA, hybridized to oligonucleotide arrays, and followed by model based expression analysis.

In order to select differentially expressed genes of interest, dChip model-based expression analysis was employed. Significant genes were identified, utilizing the dChip software, as having an average fold change of > +1.5 or < -1.5 between leiomyoma and normal myometrium and p < 0.05. Under these conditions the 226 genes in the following list were identified.
Keywords: other
 
 
Contributor(s) Hoffman PJ, Milliken DB, Davis RR, Gregg JP
Citation(s) 15374708
Submission date Aug 13, 2003
Last update date Aug 10, 2018
Contact name Jeffrey Gregg
E-mail(s) jpgregg@ucdavis.edu
Phone 916-703-0360
Organization name University of California, Davis School of Medicine
Department
Street address
City Sacramento
State/province CA
ZIP/Postal code 95817
Country USA
 
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (10)
GSM9093 Fibroid_2192
GSM9094 Fibroid_2525A
GSM9095 Fibroid_2525C
Relations
BioProject PRJNA85381

Uterine_Fibroid_vs_Normal_Myometrium header descriptions
ID_REF
VALUE Fold Change
VALUE_DET_P P-value
VALUE_2 Gene Symbol
VALUE_3 Unigene Accession Number
VALUE_4 Functionality

Data table
ID_REF VALUE VALUE_DET_P VALUE_2 VALUE_3 VALUE_4
210935_s_at -2.02 0.004849 WDR1 326791 Actin binding
217892_s_at -1.99 0.000703 EPLIN 10706 Actin cytoskeleton
214040_s_at -2.79 0.000416 GSN 290070 Actin cytoskeleton
203002_at -2.38 0.001477 AMOTL2 92186 Angiogenesis
204051_s_at 2.49 0.008072 SFRP4 105700 Apoptosis
207574_s_at -3.08 0.039976 GADD45B 110571 Apoptosis
203837_at -2.11 0.001703 MAP3K5 151988 Apoptosis
202820_at -2.78 0.000106 AHR 170087 Apoptosis
218499_at -2.41 0.006522 MST4 23643 Apoptosis
201739_at -3.76 0.046762 SGK 296323 Apoptosis
211509_s_at -1.9 0.000307 RTN4 65450 Apoptosis
212353_at 2.02 0.00085 SULF1 70823 Apoptosis
202037_s_at 3.47 0.002627 SFRP1 7306 Apoptosis
202687_s_at -3.13 0.000381 TNFSF10 83429 Apoptosis
202283_at -2.61 0.000051 SERPINF1 173594 Blood coagulation
203887_s_at -4.19 0.000774 THBD 2030 Blood coagulation
200983_x_at -2.17 0.000572 CD59 278573 Blood coagulation
202628_s_at -4.4 0.005083 SERPINE1 82085 Blood coagulation
204627_s_at -1.94 0.000616 ITGB3 87149 Blood coagulation
204955_at -2.54 0.002825 SRPX 15154 Cell adhesion

Total number of rows: 226

Table truncated, full table size 12 Kbytes.




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Supplementary data files not provided
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