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| Status |
Public on Jul 01, 2007 |
| Title |
Differential gene expression in BALB/c Npc1-/- and Npc1+/+ cerebellum |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Purkinje cells (PC) of the cerebellum degenerate in adult mice with mutations in the Niemann-Pick type C (NPC) disease 1 (Npc1) gene. We subjected BALB/c Npc1+/+ and Npc1-/- mouse cerebella from an early and a later time point of PC degeneration to a genome-wide microarray gene expression analysis. We found general underrepresentation of PC-specific transcripts, consistent with PC loss, and elevated markers of microglia activation at the later time point.
Keywords: Niemann-Pick type C, Purkinje cell degeneration
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| Overall design |
12 BALB/c Npc1 mice of the two ages P21 and P49 and the two genotypes Npc1+/+ and Npc1-/- were used, 3 replicates for each age and genotype. The animals were of the same breed and lived under identical housing conditions. All except one animal were female. The animals were not further treated, but only sacrificed at P21 or P49.
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| Contributor(s) |
Distl R, Kuban R, Komkov V, Kallwellis K, von Deimling A, Ohm TG |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Sep 29, 2006 |
| Last update date |
Jan 08, 2019 |
| Contact name |
Roland Distl |
| E-mail(s) |
roland.distl@web.de
|
| Phone |
+49-30-450-536004
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| Organization name |
Charité Universitätsmedizin Berlin
|
| Department |
Institute of Neuropathology
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| Street address |
Am Augustenburger Platz 1
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| City |
Berlin |
| ZIP/Postal code |
13353 |
| Country |
Germany |
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| Platforms (1) |
| GPL339 |
[MOE430A] Affymetrix Mouse Expression 430A Array |
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| Samples (12)
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| GSM138265 |
Differential gene expression in BALB/c Npc1-/- and Npc1+/+ cerebellum - animal No 1 |
| GSM138267 |
Differential gene expression in BALB/c Npc1-/- and Npc1+/+ cerebellum - animal No 2 |
| GSM138269 |
Differential gene expression in BALB/c Npc1-/- and Npc1+/+ cerebellum - animal No 3 |
| GSM138271 |
Differential gene expression in BALB/c Npc1-/- and Npc1+/+ cerebellum - animal No 4 |
| GSM138272 |
Differential gene expression in BALB/c Npc1-/- and Npc1+/+ cerebellum - animal No 5 |
| GSM138273 |
Differential gene expression in BALB/c Npc1-/- and Npc1+/+ cerebellum - animal No 6 |
| GSM138274 |
Differential gene expression in BALB/c Npc1-/- and Npc1+/+ cerebellum - animal No 7 |
| GSM138275 |
Differential gene expression in BALB/c Npc1-/- and Npc1+/+ cerebellum - animal No 8 |
| GSM138276 |
Differential gene expression in BALB/c Npc1-/- and Npc1+/+ cerebellum - animal No 9 |
| GSM138277 |
Differential gene expression in BALB/c Npc1-/- and Npc1+/+ cerebellum - animal No 10 |
| GSM138278 |
Differential gene expression in BALB/c Npc1-/- and Npc1+/+ cerebellum - animal No 11 |
| GSM138279 |
Differential gene expression in BALB/c Npc1-/- and Npc1+/+ cerebellum - animal No 12 |
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| Relations |
| BioProject |
PRJNA97395 |
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