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Series GSE59888 Query DataSets for GSE59888
Status Public on Jul 30, 2014
Title Epigenetic activation of neuronal gene expression by JMJD3 is required for postnatal and adult brain neurogenesis
Organism Mus musculus
Experiment type Expression profiling by array
Summary The epigenetic mechanisms that enable lifelong neurogenesis from neural stem cells (NSCs) in the adult mammalian brain are poorly understood. Here we show that JMJD3, a histone H3-lysine 27 (H3K27) demethylase, acts as a critical activator of neurogenesis.
Overall design 3 biological replicates of JMJD3 null (P9 UBC-Cre/ERT2;Jmjd3F/F) and 3 biological replicates of littermate controls were used to analyze the effect of JMJD3 deletion on gene expression.
Contributor(s) Park DH, Lim DA, Liu SJ
Citation(s) 25176653
Submission date Jul 29, 2014
Last update date Jun 14, 2018
Contact name John Liu
Organization name UCSF
Street address 35 Medical Center Way
State/province California
ZIP/Postal code 94143
Country USA
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (9)
GSM1449054 WT proliferating SVZ cells-#1
GSM1449055 WT proliferating SVZ cells-#2
GSM1449056 WT proliferating SVZ cells-#3
BioProject PRJNA256992

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE59888_RAW.tar 3.1 Mb (http)(custom) TAR
GSE59888_non-normalized.txt.gz 1.1 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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