|
| Status |
Public on Feb 14, 2004 |
| Title |
Dietary salt and renal function |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
|
| Summary |
Serum and glucocorticoid-induced kinase 1 (SGK1) activates the epithelial sodium channel (eNaC) in tubules. We examined renal SGK1 abundance in salt-adaptation and in salt-sensitive hypertension. Sprague-Dawley and Dahl salt-sensitive rats were placed on either 8% or 0.3% NaCl diets for 10 days. Plasma aldosterone levels were approximately 2.5-fold greater on 0.3% versus 8% NaCl diets in both rat strains. Both serum and glucocorticoid-induced kinase 1 transcript and protein abundance were less (P<0.01) in Sprague-Dawley rats and greater (P<0.01) in Dahl salt-sensitive rats on 8% versus 0.3% NaCl diets. The cDNA sequences of serum and glucocorticoid-induced kinase 1 in both strains of rat were the same. The present results provide evidence that the abundance of serum and glucocorticoid-induced kinase 1 in rat kidney may play a role in salt adaptation and the pathogenesis of hypertension and suggests that aldosterone is not the primary inducer of SGK1 in the Sprague-Dawley rat.
Keywords = Rattus norvegicus, Sprague Dawley, Dahl SS/Jr, kidney, NaCl diet
Keywords: other
|
| |
|
| |
|
| Contributor(s) |
Farjah M, Roxas BP, Geenen DL, Danziger RS |
| Citation(s) |
12642512 |
| Submission date |
Aug 18, 2003 |
| Last update date |
Feb 21, 2017 |
| Contact name |
Bryan Angelo P Roxas |
| E-mail(s) |
baproxas@uic.edu
|
| Phone |
312-590-3742
|
| Organization name |
University of Illinois at Chicago
|
| Street address |
900 S. Ashland Ave.
|
| City |
Chicago |
| State/province |
IL |
| ZIP/Postal code |
60607 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL85 |
[RG_U34A] Affymetrix Rat Genome U34 Array |
|
| Samples (11)
|
|
| Relations |
| BioProject |
PRJNA85391 |
Less...
More...