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| Status |
Public on Aug 31, 2014 |
| Title |
Chronic Myeloid Leukemia (CML), induced pluripotent stem cell (iPSC)-derived lin-CD34+CD45+ (iCD34) cell population |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Analysis of lin-CD34+CD45+ (iCD34+) cell population from two normal bone marrow-derived (BM1K and BM9) iPSCs and two CML (CML15 and CML17) iPSCs . CML iCD34+ cells have characteristics similar to primary CML leukemia stem cell in patients. Results provide insight into molecular profile characterized CML iCD34 and mechanism of its maintenance and drug resistance.
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| Overall design |
iCD34+ cell samples obtained from two control BM1K and BM9 iPSCs (both for the same normal donor) and CML15 and CML17 iPSCs (both from the same patient in chronic phase of CML). Each group was treated with DMSO (control) or 5 μM imatinib. The complete phenotype for iCD34+ cells: lin-CD34+CD45+CD90+CD117+CD45RA-. This population also inclyde Rhodaminelow and ALDKhigh cells.
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| |
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| Contributor(s) |
Suknuntha K, Slukvin I, Swanson S |
| Citation(s) |
26561938 |
| Submission date |
Aug 04, 2014 |
| Last update date |
Jul 18, 2019 |
| Contact name |
Scott Swanson |
| E-mail(s) |
SSWANSON@MORGRIDGEINSTITUTE.ORG
|
| Organization name |
Morgridge Institute for Research
|
| Lab |
Thomson
|
| Street address |
330 N. Orchard St
|
| City |
Madison |
| State/province |
WI |
| ZIP/Postal code |
53715 |
| Country |
USA |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA257403 |
| SRA |
SRP045234 |
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