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| Status |
Public on Jan 08, 2015 |
| Title |
A systems approach identifies networks and genes linking sleep and stress: implications for neuropathology |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Sleep dysfunction and stress susceptibility are co-morbid complex traits, which often precede and predispose patients to a variety of neuropsychiatric diseases. Here, we demonstrate multi-level organizations of genetic landscape, candidate genes, and molecular networks associated with 328 stress and sleep traits in a chronically stressed population of 338 (C57BL/6J×A/J) F2 mice. We constructed striatal gene co-expression networks, revealing functionally and cell-type-specific gene co-regulations important for stress and sleep. Using a composite ranking system, we identified network modules most relevant for 15 independent phenotypic categories, highlighting a mitochondria/synaptic module that links sleep and stress. The key network regulators of this module are overrepresented with genes implicated in neuropsychiatric diseases. Our work suggests the interplay between sleep, stress, and neuropathology emerge from genetic influences on gene expression and their collective organization through complex molecular networks, providing a framework to interrogate the mechanisms underlying sleep, stress susceptibility, and related neuropathology.
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| Overall design |
Examination of genomic and transcriptomic networks in a random subset of 100 (B6xA/J)F2 mice modeling the natural spectrum of stress susceptibility.
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| Contributor(s) |
Scarpa J, Losic B, Jiang P |
| Citation(s) |
25921536 |
| Submission date |
Aug 11, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Bojan Losic |
| E-mail(s) |
bojan.losic@mssm.edu
|
| Organization name |
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
|
| Department |
Genetics and Genomics
|
| Street address |
1425 Madison Avenue
|
| City |
new york |
| State/province |
NY |
| ZIP/Postal code |
10029 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (100)
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| Relations |
| BioProject |
PRJNA258009 |
| SRA |
SRP045426 |
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