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Series GSE6034 Query DataSets for GSE6034
Status Public on Oct 09, 2007
Title Molecular targets of proteasome inhibitor, bortezomib, on ATL cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Adult T-cell leukemia (ATL) is a fatal neoplasia derived from HTLV-1 infected T lymphocytes exhibiting constitutive activation of NF-kB. To elucidate the complex molecular mechanism of anti-tumor effect of the proteasome inhibitor, bortezomib in ATL cells, we attempted to perform gene expression profiling.
Keywords: dose response
 
Overall design Four ATL cell lines were cultured with or without bortezomib, then analysed.
 
Contributor(s) Ohyashiki JH
Citation(s) 17895889
Junko H Ohyashiki, Ryoko Hamamura, Chiaki Kobayashi, Yu Zhang, Kazuma Ohyashiki. 2008. A network biology approach evaluating the anticancer effects of bortezomib identifies SPARC as a therapeutic target in adult T-cell leukemia cells. October 2008 Volume 2008:1 Pages 85 - 98. DOI: http://0-dx-doi-org.brum.beds.ac.uk/10.2147/AABC.S4133
Submission date Oct 14, 2006
Last update date Mar 25, 2019
Contact name Junko H Ohyashiki
E-mail(s) junko@hh.iij4u.or.jp
Phone +81-3-3342-6111(ext.5999)
Fax +81-3-5381-6651
Organization name Tokyo Medical University
Department Intractable Immune System Diseases Research Center
Street address 6-7-1, Nishishinjuku, Shinjuku-ku
City Tokyo
ZIP/Postal code 160-0023
Country Japan
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (18)
GSM139044 TaY_E10_MOCK_dup1
GSM139045 TaY_E10_MOCK_dup2
GSM139046 TaY_E10_Velcade_5nM_24h
Relations
BioProject PRJNA97763

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE6034_RAW.tar 143.2 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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