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Series GSE60419 Query DataSets for GSE60419
Status Public on Jun 05, 2015
Title Cooperative target mRNA destabilization and translation inhibition by miR-58 microRNA family in C. elegans [miRNA-Seq]
Organism Caenorhabditis elegans
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary In animals, microRNAs frequently form families with related sequences. The functional relevance of miRNA families and the relative contribution of family members to target repression have remained, however, largely unexplored. Here, we used the C. elegans miR-58 miRNA family, comprised primarily of four highly abundant members: miR-58.1, miR-80, miR-81 and miR-82, as a model to investigate the redundancy of miRNA family members and their impact on target expression in an in vivo setting.
 
Overall design RNA was extracted from different miR-58 family mutants (mir-58.1, mir-80; mir-58.1 and mir-80; mir-58.1; mir-81-82) and wild-type Bristol C. elegans strain at late L4 stage and submitted to small RNA profiling with Illumina HiSeq2000. The goal was to see whether miR-58 family members can compensate each other's expression.
 
Contributor(s) Subasic D, Bruemmer A
Citation(s) 26232411
Submission date Aug 14, 2014
Last update date May 15, 2019
Contact name Deni Subasic
Organization name University of Zurich
Department Institute of Molecular Life Sciences
Lab Michael Hengartner
Street address Wintethurerstr. 190
City Zurich
ZIP/Postal code 8057
Country Switzerland
 
Platforms (1)
GPL13657 Illumina HiSeq 2000 (Caenorhabditis elegans)
Samples (10)
GSM1479374 Wild Type rep 1 [miRNA-Seq]
GSM1479375 mir-58 rep 1 [miRNA-Seq]
GSM1479376 mir-58 rep 2 [miRNA-Seq]
This SubSeries is part of SuperSeries:
GSE60421 Cooperative target mRNA destabilization and translation inhibition by miR-58 microRNA family in C. elegans
Relations
BioProject PRJNA258215
SRA SRP045498

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE60419_small_RNA_seq_miR58_processed_data_file.txt.gz 6.1 Kb (ftp)(http) TXT
SRA Run SelectorHelp
Processed data are available on Series record
Raw data are available in SRA

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