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Series GSE60447 Query DataSets for GSE60447
Status Public on Jul 01, 2015
Title Stretch-dependent genes in vascular smooth muscle cells
Organism Mus musculus
Experiment type Expression profiling by array
Summary Vascular smooth muscle cells (VSMCs) respond to biomechanical stretch with specific changes in gene expression which govern the phenotype of these cells. The mechanotransducer zyxin is a
potential candidate for regulating the expression of such genes. Using microarrays, we compared stretch-induced gene expression in wild type and zyxin-null VSMCs to define such changes in detail.
 
Overall design Wild type (WT) and zyxin-null VSMCs were stretched at 10% cyclic elongation for 6 hours and the changes in gene expression were compared under static and stretched conditions. Up to 3 biological replicates were used for each of the 4 sample types.
 
Contributor(s) Ghosh S, Hecker M
Citation(s) 26071033
Submission date Aug 15, 2014
Last update date Jul 01, 2015
Contact name Carsten Sticht
Organization name University Heidelberg
Department ZMF
Street address Theodor-Kutzer-Ufer
City Mannheim
ZIP/Postal code 68169
Country Germany
 
Platforms (1)
GPL18615 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array [CDF: Mouse4302_Mm_ENTREZG.cdf Brainarray version 17.0.0]
Samples (11)
GSM1480250 Zyxin-null VSMCs, static, biological rep1
GSM1480251 Zyxin-null VSMCs, static, biological rep3
GSM1480252 Wild type VSMCs, static, biological rep1
Relations
BioProject PRJNA258283

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE60447_RAW.tar 77.5 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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