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| Status |
Public on Aug 01, 2015 |
| Title |
Lateral ventricle SVZ: 3xTg vs WT |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Transcriptional profiling of the microdissected SVZ from 7-month-old mice
Adult neurogenesis is suppressed in the SVZ of 3xTg mice, a model of Alzheimer's disease. To better understand the underlying mechanisms of this suppression, the goals of this experiment were to compare the transcriptional profiles of the SVZ neural stem cell niche in 3xTg-AD mice versus strain controls. We used early middle-aged mice (7-months-old) rather than old mice, in order to identify genetic changes that are not caused secondarily to other degenerative changes occurring in these mice.
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| Overall design |
Two-condition experiment, 3xTg vs WT SVZ. Biological replicates: 4 for each.
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| Contributor(s) |
Hamilton LK, Fernandes KJ |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Aug 16, 2014 |
| Last update date |
Feb 02, 2018 |
| Contact name |
Karl JL Fernandes |
| E-mail(s) |
karl.jl.fernandes@umontreal.ca
|
| Organization name |
Université de Montréal
|
| Department |
Neurosciences
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| Street address |
900 Rue St-Denis, R09-474
|
| City |
Montreal |
| State/province |
Quebec |
| ZIP/Postal code |
H2X 0A9 |
| Country |
Canada |
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| Platforms (1) |
| GPL10787 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Probe Name version) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA258324 |
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