|
| Status |
Public on May 06, 2015 |
| Title |
An alternative pluripotent state confers interspecies chimaeric competency [Microarray] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Here we show that by simple modulation of extrinsic signaling pathways, a new class of pluripotent stem cells, referred to as intrinsic state-epiblast stem cells (IS-EPIs), could be efficiently derived from different stages of the early embryo. IS-EPIs share features of primed pluripotency yet are distinct from EpiSCs in their molecular characteristics and ability to colonize post-implantation embryos. We performed Microarray analysis and compared global gene expression pattern among amplified RNA samples from ESCs, EpiSCS, IS-EPIs as well as in vivo isolated Epiblasts.
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| |
|
| Overall design |
Examination of global gene expression profiles multiple pluripotent stem cell types
|
| |
|
| Contributor(s) |
Wu J |
| Citation(s) |
25945737 |
| Submission date |
Aug 19, 2014 |
| Last update date |
Feb 21, 2018 |
| Contact name |
Christopher Benner |
| E-mail(s) |
cbenner@ucsd.edu
|
| Organization name |
University of California, San Diego (UCSD)
|
| Department |
Medicine
|
| Street address |
9500 Gilman Dr. MC 0640
|
| City |
La Jolla |
| State/province |
California |
| ZIP/Postal code |
92093-0640 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
|
| Samples (12)
|
|
| This SubSeries is part of SuperSeries: |
| GSE60605 |
An alternative pluripotent state confers interspecies chimaeric competency |
|
| Relations |
| BioProject |
PRJNA258464 |
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