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| Status |
Public on Jul 24, 2020 |
| Title |
In vivo isolated HER2/neu-Prim1 Primary, Residual, and Recurrent Tumor Cells, and Recurrent Tumor Stromal Cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Residual disease represents a major obstacle to the successful treatment of breast cancer, however little is known about the biology of residual tumor cells in vivo. To identify genes differentially expressed in vivo in residual tumor cells compared to primary tumor cells or recurrent tumor cells, we used flow cytometry to isolate GFP-labeled tumor cells from primary, residual, or recurrent tumors grown orthotopically in nu/nu mice. WTA was used to amplify RNA from all tumor cells.
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| Overall design |
Three timepoints (Primary tumor, residual disease, recurrent tumor) were taken with 3-4 replicates per timepoint.
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| Contributor(s) |
Pant DK, Ruth JR, Chodosh LA |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Aug 21, 2014 |
| Last update date |
Jul 25, 2020 |
| Contact name |
Lewis Chodosh |
| E-mail(s) |
chodosh@pennmedicine.upenn.edu
|
| Phone |
(215) 898-1321
|
| Organization name |
University of Pennsylvania
|
| Department |
Cancer Biology
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| Lab |
Chodosh
|
| Street address |
421 Curie Blvd
|
| City |
Philadelphia |
| State/province |
Pennsylvania |
| ZIP/Postal code |
19104 |
| Country |
USA |
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| Platforms (1) |
| GPL19103 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [CDF: mogene10st_Mm_ENTREZG_18.0.0] |
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| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE60611 |
Tumor cells that survive oncogenic pathway inhibition exhibit cellular dormancy |
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| Relations |
| BioProject |
PRJNA258648 |
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