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Status |
Public on Sep 03, 2014 |
Title |
Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
Multiple myeloma RPMI8226 cells adapted to growth in melphalan display a shift towards Warburg metabolism and modulated oxidative stress signaling Inhibitors targeting specific enzymes in these pathways are selectively toxic to the melphalan-resistant cells.
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Overall design |
The gene expression profiles were measured on 6 batches each of control and melphalan-treated RPMI8226 and RPMI8226-LR5 cells using Illumina Human HT-12 v3 Expression BeadChip (Illumina, San Diego, CA), which enables genome-wide expression analysis (more than 47 000 transcripts) of 24 samples in parallel on a single microarray.
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Contributor(s) |
Zub KA, Sarno A, Sharma A, Young C, Sundan A, Nørregaard Jensen O, Mittelstedt M, de Sousa L, Demirovic A, Rao S, Ericsson I, Aas PA, Slupphaug G |
Citation(s) |
25769101 |
Submission date |
Sep 02, 2014 |
Last update date |
Aug 16, 2018 |
Contact name |
Animesh Sharma |
E-mail(s) |
sharma.animesh@gmail.com
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Phone |
72825335
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Organization name |
NTNU
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Department |
Cancer Research
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Lab |
PROMEC
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Street address |
Erlingskjallsons gate 1
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City |
Trondheim |
State/province |
Trondelag |
ZIP/Postal code |
7030 |
Country |
Norway |
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Platforms (1) |
GPL6947 |
Illumina HumanHT-12 V3.0 expression beadchip |
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Samples (24)
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Relations |
BioProject |
PRJNA260009 |
Supplementary file |
Size |
Download |
File type/resource |
GSE60970_RAW.tar |
6.2 Mb |
(http)(custom) |
TAR |
GSE60970_non-normalized.txt.gz |
12.4 Mb |
(ftp)(http) |
TXT |
Processed data included within Sample table |
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