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Series GSE60970 Query DataSets for GSE60970
Status Public on Sep 03, 2014
Title Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Multiple myeloma RPMI8226 cells adapted to growth in melphalan display a shift towards Warburg metabolism and modulated oxidative stress signaling
Inhibitors targeting specific enzymes in these pathways are selectively toxic to the melphalan-resistant cells.
 
Overall design The gene expression profiles were measured on 6 batches each of control and melphalan-treated RPMI8226 and RPMI8226-LR5 cells using Illumina Human HT-12 v3 Expression BeadChip (Illumina, San Diego, CA), which enables genome-wide expression analysis (more than 47 000 transcripts) of 24 samples in parallel on a single microarray.
 
Contributor(s) Zub KA, Sarno A, Sharma A, Young C, Sundan A, Nørregaard Jensen O, Mittelstedt M, de Sousa L, Demirovic A, Rao S, Ericsson I, Aas PA, Slupphaug G
Citation(s) 25769101
Submission date Sep 02, 2014
Last update date Aug 16, 2018
Contact name Animesh Sharma
E-mail(s) sharma.animesh@gmail.com
Phone 72825335
Organization name NTNU
Department Cancer Research
Lab PROMEC
Street address Erlingskjallsons gate 1
City Trondheim
State/province Trondelag
ZIP/Postal code 7030
Country Norway
 
Platforms (1)
GPL6947 Illumina HumanHT-12 V3.0 expression beadchip
Samples (24)
GSM1494742 8226_light_control_0_6h
GSM1494743 8226_heavy_treated_6h
GSM1494744 8226_LR5_light_heavy_control_0_6h
Relations
BioProject PRJNA260009

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE60970_RAW.tar 6.2 Mb (http)(custom) TAR
GSE60970_non-normalized.txt.gz 12.4 Mb (ftp)(http) TXT
Processed data included within Sample table

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