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| Status |
Public on Oct 21, 2014 |
| Title |
MicroRNA expression data from H1N1 influenza virus infected mouse lung |
| Platform organism |
synthetic construct |
| Sample organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Influenza A virus is a kind of single negative-stranded RNA virus which belongs to the Orthomyxoviridae family. It can cause localized outbreak or worldwide epidemic in a short time for its great contagiosity, fast spread speed and a wide range of host, and H1N1 influenza virus is a strong pathogenic subtype of influenza A virus. Influenza A virus infection has been shown to alter miRNA expression both in cultured cells and in animal models.
We used microRNA microarrays to detail the programme of microRNA expression and identified distinct classes of differentially regulated microRNAs during this process.
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| Overall design |
Mice lungs infected with PR8 H1N1 influenza virus were separately selected for RNA extraction and hybridization on Affymetrix microRNA microarrays. We sought to obtain microRNAs expression level in different stages of infection. To that end, we selected two time-points: 2 days and 5 days.
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| Contributor(s) |
Cui X, Bao Y |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Oct 20, 2014 |
| Last update date |
May 02, 2017 |
| Contact name |
yanyan bao |
| E-mail(s) |
baoyanyan885@126.com
|
| Organization name |
Biosafety Laboratory, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences
|
| Street address |
Dongzhimen South Street
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| City |
beijing |
| ZIP/Postal code |
100700 |
| Country |
China |
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| Platforms (1) |
| GPL19117 |
[miRNA-4] Affymetrix Multispecies miRNA-4 Array |
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| Samples (9)
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| GSM1527856 |
mouse lung infected 2 days, biological rep1 |
| GSM1527857 |
mouse lung infected 2 days, biological rep2 |
| GSM1527858 |
mouse lung infected 2 days, biological rep3 |
| GSM1527859 |
mouse lung infected 5 days, biological rep1 |
| GSM1527860 |
mouse lung infected 5 days, biological rep2 |
| GSM1527861 |
mouse lung infected 5 days, biological rep3 |
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| Relations |
| BioProject |
PRJNA264288 |
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