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Series GSE6285 Query DataSets for GSE6285
Status Public on Jan 15, 2008
Title Expression data from brains of mice fed four different diets
Organism Mus musculus
Experiment type Expression profiling by array
Summary Beyond the DNA sequence difference between humans and closely related apes, there are large differences in the environments that these species experience. One prominent example for this is diet. The human diet diverges from those of other primates in various aspects, such as having a high calorie and protein content, as well as being cooked. Here, we used a laboratory mouse model to identify gene expression differences related to dietary differences.
Keywords: diet
Overall design We fed four groups of six genetically identical 8-week-old female NMR1 mice one of four diets ad libidum: (1) a diet consisting of vegetables, fruit and yogurt identical to the diet fed to chimpanzees in our ape facility ('Chimpanzee'); (2) a diet consisting exclusively of McDonalds. fast food ('FastFood'); (3) a diet consisting of cooked food eaten by our staff in the Institute cafeteria ('HumanCafe'); (4) the mouse pellet diet on which they were raised ('Pellet'). At the end of a 2-week period, mice were euthanized by cervical dislocation and both liver and brain (right cerebral hemisphere) tissue were dissected. RNA was extracted from the 24 liver and brain samples as per established lab protocols and processed in two batches (containing equal numbers of individuals from all groups).
Contributor(s) Somel M, Creely H, Franz H, Mueller U, Lachmann M, Paabo S, Khaitovich P
Citation(s) 18231591
Submission date Nov 15, 2006
Last update date Feb 11, 2019
Contact name Mehmet Somel
Phone +49-(0)341-3550-530
Fax +49-(0)341-3550-555
Organization name Max Planck Institute for Evolutionary Anthropology
Department Evolutionary Genetics
Street address Deutscher Platz 6
City Leipzig
ZIP/Postal code D-04103
Country Germany
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (24)
GSM144526 Mouse_Brain_ChimpanzeeDiet__Batch_1__replicate_1
GSM144527 Mouse_Brain_ChimpanzeeDiet__Batch_1__replicate_2
GSM144528 Mouse_Brain_ChimpanzeeDiet__Batch_1__replicate_3
BioProject PRJNA100535

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Supplementary file Size Download File type/resource
GSE6285_RAW.tar 137.2 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file

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