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Series GSE63347 Query DataSets for GSE63347
Status Public on Mar 02, 2015
Title DNA methylation profiles of brain samples from Down Syndrome subjects and controls.
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 486,000 CpGs. Dataset included 71 samples from multiple brain regions (cerebellum, temporal/occipital/frontal cortex). The goal was to evalute the effect of trisomy 21 on DNA methylation levels and epigenetic age.
Explanation of characteristics variables in supplementary file Explanation_of_characteristic_variables2.docx
 
Overall design Bisulphite converted DNA from the 71 samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip. Trisomy 21 (Down syndrome status) was related to CpGs.
 
Contributor(s) Horvath S
Citation(s) 25678027
Submission date Nov 17, 2014
Last update date Mar 22, 2019
Contact name Steve Horvath
E-mail(s) shorvath@altoslabs.com
Organization name University of California, Los Angeles
Department Human Genetics
Lab Horvath
Street address 695 Charles E. Young Drive South, Box 708822
City Los Angeles
State/province CA
ZIP/Postal code 90095-7088
Country USA
 
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (71)
GSM1546373 genomic DNA from Brain Hippocampus Sample1
GSM1546374 genomic DNA from Brain Frontal Cortex Sample2
GSM1546375 genomic DNA from Brain Temporal Cortex Sample3
Relations
BioProject PRJNA267550

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE63347_Explanation_of_characteristic_variables2.txt.gz 825 b (ftp)(http) TXT
GSE63347_RAW.tar 183.1 Mb (http)(custom) TAR
GSE63347_datSignal.csv.gz 575.1 Mb (ftp)(http) CSV
Processed data included within Sample table
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