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| Status |
Public on Dec 23, 2014 |
| Title |
Ets homologous factor regulates pathways controlling response to injury in Calu-3 airway epithelial cells [DNAse-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Other
|
| Summary |
Ets homologous factor (EHF) is an Ets family transcription factor expressed in many epithelial cell types including those lining the respiratory system. Disruption of the airway epithelium is central to many lung diseases, and a network of transcription factors coordinates its normal function. EHF can act as a transcriptional activator or a repressor, though its targets in lung epithelial cells are largely uncharacterized. Chromatin immunoprecipitation followed by deep sequencing (ChIP-seq), showed that the majority of EHF binding sites in lung epithelial cells are intergenic or intronic and coincide with putative enhancers, marked by specific histone modifications and increased DNase hypersensitivity.
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| Overall design |
Examination of open chromatin region in Calu-3 cells with 1 replicate
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| Contributor(s) |
Crawford G, Song L, Fossum S, Mutolo M, Yang R, Dang H, O'Neal W, Knowles M, Leir SH, Harris A |
| Citation(s) |
25414352 |
| Submission date |
Nov 18, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Ann Harris |
| Organization name |
Lurie Children's Hospital of Chicago Research Center
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| Department |
Human Molecular Genetics
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| Street address |
2430 N Halsted Street Box 211
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| City |
Chicago |
| State/province |
IL |
| ZIP/Postal code |
60614 |
| Country |
USA |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (1) |
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| This SubSeries is part of SuperSeries: |
| GSE63400 |
Ets homologous factor regulates pathways controlling response to injury in Calu-3 airway epithelial cells |
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| Relations |
| BioProject |
PRJNA267664 |
| SRA |
SRP049990 |
